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Lecture 5

Print out the following information:

bulletFats
bulletCholesterol
bulletDiscussion on receptor-mediated endocytosis ( example: LDL receptors)

 

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Arteriosclerosis

The coronary arteries arise at the point of maximum blood pressure in the circulatory system. Over the course of time, the arterial walls are apt to lose elasticity, which limits the amount of blood that can surge through them and hence limits the supply of oxygen to the heart. This condition is known as arteriosclerosis.

Atherosclerosis

Fatty deposits, called plaque, may accumulate on the interior surface of the coronary arteries. This is particularly common in people who have high levels of cholesterol in their blood. Plaque deposits reduce the bore of the coronary arteries and thus the amount of blood they can carry.

Atherosclerosis (usually along with arteriosclerosis) may
bulletso limit the blood supply to the heart that during times of stress the heart muscle is so deprived of oxygen that the pain of angina is created.
bullettrigger the formation of a clot causing a coronary thrombosis. This stops the flow of blood through the vessel and the capillary network it supplies causing a heart attack. The portion of the heart muscle deprived of oxygen dies quickly of oxygen starvation. If the area is not too large, the undamaged part of the heart can, in time, compensate for the damage.

Coronary bypass surgery uses segments of leg veins to bypass the clogged portions of the coronary arteries.